Sponsored by an educational grant from Ipsen
First thanks from everybody to Ipsen Laboratories for supporting this interesting health symposium on testosterone therapy and looking as the title mentions to men's mind, brain, body and spirit.
From this larger study it is already well known that 1 out of 10 men over 50 have some form of hypogonadism and over 60 years it is 1 out of 5 men so more than 20% but most of this are not diagnosed and of course not treated. There is still a lot of need for awareness and information in this field. You see that in the US who is leading in this field about only 5 to a maximum of 10 percent of these men are diagnosed and treated. And unfortunately in Europe, it is much, much lower and these are even a somewhat optimistic number that is saying that among all of these men only 2 percent are treated.
So, as I said the Massachusetts Male Aging Study is the largest review longitudinal of the effect of male hormones on overall mortality. This was done on 3,500 men that were followed for 17 years so this is really a very long period of follow-up and we miss this type of studies, there are very few and this is definitely the most important one. And in this 3,500 men testosterone were measured and they were stratified into five categories with an increment of 2,000 ng and multivariate analysis were done in these five categories regarding the eventual predictive association of testosterone, overall mortality, cardiovascular disease, prostate cancer and the reasons on this, again as I said, were presented very recently and will be updated tomorrow.
Following this 3,500 men for 17 years the age adjusted as a ratio for men with a total testosterone which is below 200, that is quite low, and with a total testosterone of 400 to 500 you can see that it has an impact on survival on health because the overall mortality is increased by 1.93 which is close to double, close to two so that is very important. Cancer death is three times higher than for people who have normal testosterone and this affects different types of cancer so you see it is not just a quality of life and sex and things that too many people think. And there is close to two, a 1.9 fold (inaudible) increase for cardiovascular deaths.
Testosterone affects most organs as it is listed here. It affects the brain the muscle, bone, liver and skin.
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