Curriculum vitae:
Education
- Scarborough High School for Boys 1965-1972
- Manchester University Medical School 1972-1978
Qualifications
- Bachelor of Science 2:1 Physiology BSc (Hons) 1975
- Bachelor of Medicine & Surgery with Honours MBChB (Hons) 1978
- Membership of Royal College of Physicians MRCP 1981
- Doctorate of Medicine MD 1985
- Fellowship of Royal College of Physicians FRCP 1993
Postgraduate experience
I started my general professional training in medicine during house posts at the Manchester Royal Infirmary and senior house officer posts at Wythenshawe and Withington Hospitals in Manchester. I extended my general professional training to include neurology and diabetes care at registrar level at the Bristol Royal Infirmary. My specialist training in cardiology began in 1983 and was completed in 1988. Registrar and senior registrar posts in cardiology provided training opportunities at the Bristol Royal Infirmary, Bristol Children’s Hospital and St George’s Hospital, London. I was appointed General Physician & Cardiologist to the Royal Hallamshire Hospital in 1988, taking up the post in January 1989. I am a Clinical Senior Lecturer in Medicine for the University of Sheffield Medical School.
Management experience
- I was Clinical Director of Medicine at the Royal Hallamshire Hospital from 1994 to 1998 and Deputy Clinical Director until April 2002.
- I was the Royal College of Physicians Deputy Regional Adviser (North Trent) from September 1999-June 2000, then Regional Advisor from July 2000 – July 2002. I am currently the Royal College of Physicians CPD advisor, and Training Adviser for General Internal Medicine for the North Trent region.
- I have been a member of the Tobacco Advisory Group of the Royal College of Physicians since 1995, and was on the working party that produced Smoking and the Young (1992) and Tobacco Addiction (2000).
- I sit on the Clinical Affairs Board of the Royal College of Physicians and am on the editorial board of Clinical Medicine. I was elected to sit on the Council of the Royal College of Physicians in 2002.
- I have been involved with the training of cardiologists since my appointment in 1989 and am a member of the Cardiology Education Committee of Trent Regional Health Authority.
Research
My research interests currently include vascular effects of sex hormones, drug therapy for atrial fibrillation, and genetic influences on the development of ischaemic heart disease. I have published over 120 main papers in scientific peer-reviewed journals.
I am an adviser and act as a reviewer to the following journals:
- British Dental Journal
- British Heart Journal
- British Journal of Clinical Pharmacology
- Drugs
- Drugs and Ageing
- European Heart Journal
- European Journal of General Practice
- Eye
- Hospital Update
- Journal of Royal College of Physicians
- Lancet
- Postgraduate Medical Journal
I am an examiner for the University of Sheffield School of Medicine and School of Dentistry, and for the Membership of the Royal College of Physicians and its Faculty of Occupational Medicine.
I am an External Clinical Examiner for the University of Manchester and have examined postgraduate research theses for the Universities of London and Aberdeen.
Clinical workload
My clinical work is that of a physician and cardiologist.
Up to August 2003, I was on take for unselected medical emergencies on a 1 in 10 rota. From August 2003, I and my two colleagues have been responsible for the care of all patients admitted with cardiac emergencies to the Royal Hallamshire Hospital. This includes the clinical supervision of a 5-bedded Coronary Care Unit and a 16-bedded acute cardiology ward. One week in 12, I spend at the Regional Cardiac Centre (Northern General Hospital) where I am responsible for cardiac emergencies admitted to that hospital and transferred patients from the surrounding District General Hospitals.
I personally see patients in three clinics per week, as well as being responsible for one of the three Rapid Access Chest Pain clinics per week.
With my two colleagues I am responsible for the provision of a full non-invasive cardiological investigative service to the central campus of the Sheffield Teaching Hospitals.
I perform invasive cardiological procedures at the neighbouring Northern General Hospital site (about 100 procedures per year).
Publications
- English KM, Steeds R, Jones TH, Channer KS. Testosterone and coronary
heart disease: is there a link? QJM. 1997; 90(12): 787-791. (Review).
- Channer KS, English KM. Hormone replacement therapy in postmenopausal
women and cardiovascular risk. Lancet. 1999; 353(9163): 1528. (Letter).
- English KM, Steeds RP, Jones TH, Diver MJ, Channer KS. Low-dose
transdermal testosterone therapy improves angina threshold in men with
chronic stable angina: A randomized, double-blind, placebo-controlled study.
Circulation. 2000; 102(16): 1906-1911.
- Pugh PJ, English KM, Jones TH, Channer KS.Testosterone: a natural tonic
for the failing heart? QJM. 2000; 93(10): 689-694. (Review).
- English KM, Jones RD, Jones TH, Morice AH, Channer KS. Aging reduces the responsiveness of coronary arteries from male Wistar
rats to the vasodilatory action of testosterone. Clin Sci. 2000; 99(1):
77-82.
- English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, Channer KS. Men with
coronary artery disease have lower levels of androgens than men with normal
coronary angiograms. Eur Heart J. 2000; 21(11): 890-894.
- English KM, Pugh PJ, Channer KS. Effects of tamoxifen on endothelial
function and cardiovascular risk factors in men with advanced
atherosclerosis. Circulation. 2001; 104(24): E146-147. (Letter).
- English KM, Jones RD, Jones TH, Morice AH, Channer KS. Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries. Horm
Metab Res. 2001; 33(11): 645-652.
- English KM, Pugh PJ, Parry H, Scutt NE, Channer KS, Jones TH. Effect of
cigarette smoking on levels of bioavailable testosterone in healthy men.
Clin Sci. 2001; 100(6): 661-665.
- English KM, Jones RD, Jones TH, Morice AH, Channer KS. Testosterone acts
as a coronary vasodilator by a calcium antagonistic action. J Endocrinol
Invest. 2002; 25(5): 455-458.
- Jones RD, English KM, Pugh PJ, Morice AH, Jones TH, Channer KS. Pulmonary
vasodilatory action of testosterone: evidence of a calcium antagonistic
action. J Cardiovasc Pharmacol. 2002; 39(6): 814-823.
- Pugh PJ, Jones RD, Jones TH, Channer KS. Intrinsic responses of rat coronary arteries in vitro: influence of testosterone, calcium, and effective transmural
pressure. Endocrine 2002; 19(2): 155-161.
- Pugh PJ, Jones RD, Jones TH, Channer KS. Heart failure as an inflammatory
condition: potential role for androgens as immune modulators. Eur J Heart
Fail. 2002; 4(6): 673-80. (Review).
- Jones RD, Pugh PJ, Hall J, Channer KS, Jones TH. Altered circulating
hormone levels, endothelial function and vascular reactivity in the
testicular feminised mouse. Eur J Endocrinol. 2003; 148(1): 111-120.
- Channer KS, Jones TH. Cardiovascular effects of testosterone: implications
of the "male menopause"? Heart. 2003; 89(2): 121-122. (Editorial).
- Jones RD, Malkin CJ, Channer KS, Jones TH. Low levels of endogenous
androgens increase the risk of atherosclerosis in elderly men: further
supportive data. J Clin Endocrinol Metab. 2003; 88(3): 1403-1404. (Letter).
- Jones RD, Pugh PJ, Jones TH, Channer KS. The vasodilatory action of
testosterone: a potassium-channel opening or a calcium antagonistic action?
Br J Pharmacol. 2003; 138(5): 733-744. (Review).
- Pugh PJ, Jones TH, Channer KS. Acute haemodynamic effects of testosterone
in men with chronic heart failure. Eur Heart J. 2003; 24(10): 909-915.
- Malkin CJ, Pugh PJ, Jones TH, Channer KS. Testosterone for secondary
prevention in men with ischaemic heart disease? QJM. 2003; 96(7): 521-529.
(Review).
- Malkin CJ, Pugh PJ, Jones RD, Jones TH, Channer KS. Testosterone as a
protective factor against atherosclerosis: immuno-modulation and influence
upon plaque development and stability. J Endocrinol. 2003; 178(3): 373-380.
(Review).
- Jones RD, Ruban LN, Morton IE, Roberts SA, English KM, Channer KS, Jones TH.
Testosterone inhibits the prostaglandin F2alpha-mediated increase in
intracellular calcium in A7r5 aortic smooth muscle cells: evidence of an
antagonistic action upon store-operated calcium channels. J Endocrinol.
2003; 178(3): 381-393.
- Malkin CJ, Morris PD, Pugh PJ, English KM, Channer KS. Effect of testosterone therapy on QT dispersion in men with heart failure. Am J Cardiol. 2003; 92(10): 1241-1243.
- Pugh PJ, Jones RD, West JN, Jones TH, Channer KS. Testosterone improves functional capacity and symptoms in men with chronic heart failure.
Heart 2004; In Press
- Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH, Channer KS. Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart 2004; In Press
Other Research Publications:
- Steeds RP, Fletcher J, Parry H, Chowdhary S, Channer KS, West J, Townend JN.
The angiotensin-converting enzyme gene I/D polymorphism and heart rate variability following acute myocardial infarction. Clin Auton Res. 2002 Apr;12(2):66-71.
- Di Bitondo R, Cameron CL, Daly ME, Croft SA, Steeds RP, Channer KS, Samani NJ, Lillicrap D, Winship PR. The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction. Br J Haematol. 2001 Dec;115(3):701-6.
- Croft SA, Samani NJ, Teare MD, Hampton KK, Steeds RP, Channer KS, Daly ME. Novel platelet membrane glycoprotein VI dimorphism is a risk factor for myocardial infarction. Circulation. 2001 Sep 25;104(13):1459-63.
- Steeds RP, Wardle A, Smith PD, Martin D, Channer KS, Samani NJ. Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction. Atherosclerosis. 2001 Jan;154(1):123-8.
- Hough RE, Hampton KK, Preston FE, Channer KS, West J, Makris M. Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors. Br J Haematol. 2000 Dec;111(3):974-9. (Review).
- Gedge J, Orme S, Hampton KK, Channer KS, Hendra TJ. A comparison of a low-dose warfarin induction regimen with the modified Fennerty regimen in elderly inpatients. Age Ageing. 2000 Jan;29(1):31-4.
- Noble TJ, Morice AH, Channer KS, Milnes P, Harris ND, Brown BH. Monitoring patients with left ventricular failure by electrical impedance tomography. Eur J Heart Fail. 1999 Dec;1(4):379-84.
- Steeds RP, Toole LO, Channer KS, Morice AH. Human vascular reactivity and polymorphisms of the angiotensin-converting enzyme and the angiotensin type 1 receptor genes. J Vasc Res. 1999 Nov-Dec;36(6):445-55.
- Orme S, Ralph SG, Birchall A, Lawson-Matthew P, McLean K, Channer KS. The normal range for inter-arm differences in blood pressure. Age Ageing. 1999 Oct;28(6):537-42.
- Nayak N, Anderson JB, Channer KS. Spontaneous subcapsular renal haemorrhage presenting with pleuritic chest pain. Urol Int. 1999;62(4):217-9.
- Croft SA, Hampton KK, Sorrell JA, Steeds RP, Channer KS, Samani NJ, Daly ME.
The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction. Br J Haematol. 1999 Sep;106(3):771-6.
- Steeds RP, Birchall AS, Smith M, Channer KS. An open label, randomised, crossover study comparing sotalol and atenolol in the treatment of symptomatic paroxysmal atrial fibrillation. Heart. 1999 Aug;82(2):170-5.
- Croft SA, Daly ME, Steeds RP, Channer KS, Samani NJ, Hampton KK. The prothrombin 20210A allele and its association with myocardial infarction.Thromb Haemost. 1999 Jun;81(6):861-4.
- Steeds RP, Channer KS. Related Articles, Links Recent advances in the management of unstable angina and non-Q-wave myocardial infarction.Br J Clin Pharmacol. 1998 Oct;46(4):335-41. Review.
- Oates A, Jackson PR, Austin CA, Channer KS. A new regimen for starting warfarin therapy in out-patients. Br J Clin Pharmacol. 1998 Aug;46(2):157-61.
- Wilson AT, Channer KS. Hypoxaemia and supplemental oxygen therapy in the first 24 hours after myocardial infarction: the role of pulse oximetry. J R Coll Physicians Lond. 1997 Nov-Dec;31(6):657-61.
- Silcocks PB, Munro JF, Steeds RP, Channer KS. Prognostic implications of qualitative assessment of left ventricular function compared to simple routine quantitative echocardiography. Heart. 1997 Sep;78(3):237-42.
- Steeds RP, Thompson JS, Channer KS, Morice AH. Response of normoxic pulmonary arteries of the rat in the resting and contracted state to NO synthase blockade.Br J Pharmacol. 1997 Sep;122(1):99-102.
- Lawson-Matthew PJ, Ionescu A, McHugh P, Channer KS. Evaluation of a protocol to select patients of all ages for cardioversion from atrial fibrillation. Age Ageing. 1997 Jul;26(4):247-52.
- Steeds RP, Channer KS. How important is family history in ischaemic heart disease? QJM. 1997 Jun;90(6):427-30.
- Phillips WS, Smith J, Greaves M, Preston FE, Channer KS. An evaluation and improvement program for inpatient anticoagulant control. Thromb Haemost. 1997 Feb;77(2):283-8.
- Fodden DI, Crosby AC, Channer KS. Doppler measurement of cardiac output during cardiopulmonary resuscitation. J Accid Emerg Med. 1996 Nov;13(6):379-82.
- Channer KS, Barrow D, Barrow R, Osborne M, Ives G. Changes in haemodynamic parameters following Tai Chi Chuan and aerobic exercise in patients recovering from acute myocardial infarction. Postgrad Med J. 1996 Jun;72(848):349-51.
- Lam FY, Wilson AT, Channer KS. The effect of meals of differing composition on exercise tolerance in patients with angina pectoris. Eur Heart J. 1996 Mar;17(3):394-8.
- Woodmansey PA, O'Toole L, Channer KS, Morice AH. Acute pulmonary vasodilatory properties of amlodipine in humans with pulmonary hypertension. Heart. 1996 Feb;75(2):171-3.
- Lawson-Matthew PJ, McLean KA, Dent M, Austin CA, Channer KS. Xamoterol improves the control of chronic atrial fibrillation in elderly patients. Age Ageing. 1995 Jul;24(4):321-5.
- White T, Woodmansey P, Ferguson DG, Channer KS. Improving the interpretation of electrocardiographs in an accident and emergency department. Postgrad Med J. 1995 Mar;71(833):132-5.
- Woodmansey PA, Zhang F, Channer KS, Morice AH. Effect of the calcium antagonist amlodipine on the two phases of hypoxic pulmonary vasoconstriction in rat large and small isolated pulmonary arteries. J Cardiovasc Pharmacol. 1995 Feb;25(2):324-9.
- Dobson PM, Caldicott LD, Gerrish SP, Cole JR, Channer KS. Changes in haemodynamic variables during transurethral resection of the prostate: comparison of general and spinal anaesthesia. Br J Anaesth. 1994 Mar;72(3):267-71.
- Channer KS, McLean KA, Lawson-Matthew P, Richardson M. Combination diuretic treatment in severe heart failure: a randomised controlled trial. Br Heart J. 1994 Feb;71(2):146-50.
- Channer KS, James MA, MacConnell T, Rees JR. Beta-adrenoceptor blockers in atrial fibrillation: the importance of partial agonist activity. Br J Clin Pharmacol. 1994 Jan;37(1):53-7.
- Woodmansey PA, Zhang F, Channer KS, Morice AH. Vasodilatory action of the calcium antagonist amlodipine on large and resistance pulmonary arteries from normoxic and chronically hypoxic rats. Clin Sci (Lond). 1993 Sep;85(3):361-6.
- Caldicott LD, Hawley K, Heppell R, Woodmansey PA, Channer KS. Intravenous enoximone or dobutamine for severe heart failure after acute myocardial infarction: a randomized double-blind trial. Eur Heart J. 1993 May;14(5):696-700.
- Woodmansey PA, Stewart AG, Morice AH, Channer KS. Amlodipine in patients with angina uncontrolled by atenolol. A double blind placebo controlled cross over trial. Eur J Clin Pharmacol. 1993;45(2):107-11.
- Hawley SK, Channer KS. Relative effects of fat-, carbohydrate- and protein-containing liquid diets on cardiac output in healthy adult subjects. Clin Sci (Lond). 1992 Oct;83(4):483-7.
- Channer KS The drug treatment of atrial fibrillation. Br J Clin Pharmacol. 1991 Sep;32(3):267-73.
- James MA, Papouchado M, Channer KS, Jones JV, Marlow HF, Bastain W, Barker NP, Harry JD, Wardleworth AG. The effect of oral dosing of xamoterol on systolic time intervals in man and xamoterol plasma concentrations in heart failure patients. Br J Clin Pharmacol. 1990 Apr;29(4):447-53.
- Channer KS, Bukis E, Hartnell G, Rees JR. Myocardial bridging of the coronary arteries.Clin Radiol. 1989 Jul;40(4):355-9.
- Channer KS, Jones JV. The contribution of atrial systole to mitral diastolic blood flow increases during exercise in humans. J Physiol. 1989 Apr;411:53-61.
- James MA, Channer KS, Papouchado M, Rees JR. Improved control of atrial fibrillation with combined pindolol and digoxin therapy. Eur Heart J. 1989 Jan;10(1):83-90.
- Channer KS, Jones JV. Atrial systole: its role in normal and diseased hearts. Clin Sci (Lond). 1988 Jul;75(1):1-4. Review.
- Channer KS, Channer JL, Campbell MJ, Rees JR. Cardiomyopathy in the Kearns-Sayre syndrome. Br Heart J. 1988 Apr;59(4):486-90.
- Channer KS, Hutter JA, George M. Unruptured aneurysm of the sinus of Valsalva presenting with ventricular tachycardia. Eur Heart J. 1988 Feb;9(2):186-90.
- Channer KS, James MA, Papouchado M, Rees JR. Failure of a negative exercise test to reassure patients with chest pain. Q J Med. 1987 Apr;63(240):315-22.
- Channer KS, Papouchado M, James MA, Pitcher DW, Rees JR. Towards improved control of atrial fibrillation. Eur Heart J. 1987 Feb;8(2):141-7.
- Channer KS, Culling W, Wilde P, Jones JV. Estimation of left ventricular end-diastolic pressure by pulsed Doppler ultrasound. Lancet. 1986 May 3;1(8488):1005-7.
- Channer KS, Virjee JP. The effect of size and shape of tablets on their esophageal transit. J Clin Pharmacol. 1986 Feb;26(2):141-6.
- Channer KS, Papouchado M, James MA, Rees JR. Anxiety and depression in patients with chest pain referred for exercise testing. Lancet. 1985 Oct 12;2(8459):820-3.
- Channer KS, Virjee JP. Oesophageal function tests: are they of value? Clin Radiol. 1985 Sep;36(5):493-6.
- Channer KS, Jackson PC, O'Brien I, Corrall RJ, Coles DR, Davies ER, Virjee JP. Oesophageal function in diabetes mellitus and its association with autonomic neuropathy. Diabet Med. 1985 Sep;2(5):378-82.
- Channer KS, Virjee JP. The effect of formulation on oesophageal transit. J Pharm Pharmacol. 1985 Feb;37(2):126-9.
- Channer KS, Roberts CJ. Effect of delayed esophageal transit on acetaminophen absorption. Clin Pharmacol Ther. 1985 Jan;37(1):72-6.
- Channer KS, Dent M, Roberts CJ. The effect of posture at the time of administration on the central depressant effects of the new hypnotic zopiclone.Br J Clin Pharmacol. 1984 Dec;18(6):879-86.
- Channer KS, Roberts CJ. Antipyrine absorption after delayed oesophageal capsule transit. Br J Clin Pharmacol. 1984 Aug;18(2):250-3.
- Channer KS, Bell J, Virjee JP. Effect of left atrial size on the oesophageal transit of capsules. Br Heart J. 1984 Aug;52(2):223-7.
- Channer KS, Bolton R, Al-Hilli S, Nakielny R, Virjee JP. The effect of glucagon on the swallowing of capsules. Br J Clin Pharmacol. 1983 Oct;16(4):456-8.
- Channer KS, Wolinski A, Kaye B, Virjee J. The effect of hyoscine butylbromide on the swallowing of capsules. Br J Clin Pharmacol. 1983 May;15(5):560-3.
return to view all presentations
Copyright © 2006 ISSAM